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A16Z is a numeronym that represents the venture capital firm Andreessen Horowitz. The numeronym is the first and last letter of the firm with the character count in-between.
Techopedia Explains A16Z
Numeronyms are somewhat of an insider’s joke for developers as most non-techies wouldn’t be aware of the concept. Other common numeronyms include I18N (for internationalization) and L10N (for localization).
Marc Andreessen is considered by many to be a living legend in Silicon Valley. As the co-founder of Netscape, he is widely considered the father of the modern Web browser. As such, his VC investments are tech-centric.
