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The term “bio break” or “bio-break” in IT is a polite way to talk about taking a bathroom break. Example: “I was coding away on that project for hours, and I had to take a bio-break.”
In general, bio-break is a much more polite and business-friendly choice than saying someone needs to “use the potty” or “go to the bathroom,” or even “visit the john.” But it is also a way that techies and others neatly contrast the world of the keyboard and monitor with the "meat-space," the physical world outside of the Internet's reach. The term bio-break really distinguishes between the realities and necessities of the digital world, where bathroom breaks do not apply, and the physical world in an office or workstation space, where they do. The term can also be useful in chatting or instant messaging.